Deliverables

Below are listed the deliverables that were approved to date within the PERMIT project. 

The PERMIT Scientific and Ethics advisory boards were constituted and met for a first time to provide guidance for the PERMIT project.

The PERMIT Scientific and Ethics advisory boards met after 15 months of the project and provided their insight.

This inventory was performed to complement the development of the methodological recommendations. It summarizes collected input on the ethical implications of personalised medicine research from the perspective of ethics experts as well as patient representatives

The PERMIT project will collect minimal data, and a clear plan has been established for its management.

The PERMIT Scientific and Ethics advisory boards were consulted after the development of the recommendations for their advice and insight.

A scoping review was performed to map the main methods being applied for the design and management of stratification and validation cohorts.

A scoping review was performed to map the main methods being applied when stratifying patients using machine-learning methods.

A scoping review was performed to map the main preclinical methods being applied for the development of personalised medicine technologies.

A scoping review was performed to map the main designs being applied in personalised medicine clinical trials.

Following the series of scoping reviews a common workshop took place to analyse the identified gaps within and across stages of the personalised medicine pipeline.

The recommendations for the use machine learning for patient stratification are presented and their development is described.

​​​​​​​The recommendations for the validation process of machine learning patient stratification are presented and their development is described.

An anonymous survey was distributed to Industry representatives to better understand the methods and approaches applied for the development of personalised medicine technologies.

The PERMIT project defined its approach to communication and dissemination and defined the actions it would take to boost the implementation of its results.

The material used to developed the PERMIT training series is presented.

Certain research questions were identified throughout the PERMIT project and are summarized in this report. These questions could be addressed in future initiatives, as personalised medicine research continues to evolve.